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Wikipedia - Rizatriptan

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Rizatriptan
Systematic (IUPAC) name
N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
Identifiers
CAS number 145202-66-0
ATC code N02CC04
PubChem CID 5078
IUPHAR ligand ID 51
DrugBank APRD00008
Chemical data
Formula C15H19N5 
Mol. mass 269.345 g/mol
Pharmacokinetic data
Bioavailability 45%
Protein binding 14%
Metabolism by monoamine oxidase
Half-life 2–3 hours
Excretion 82% urine; 12% faeces
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes Oral
 YesY(what is this?)  (verify)

Rizatriptan (Maxalt) is a 5-HT1 agonist triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).

Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.

Rizatriptan is available only by prescription in the United States, Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom, Italy (as Rizaliv) and Israel (as Rizalt).

Contents

[edit] Use

Rizatriptan is used to treat acute migraine attacks. It does not prevent future migraine attacks.

[edit] Indications

[edit] Contraindications

[edit] Adverse effects

Severe:

Atypical sensations:

Cardiovascular:

Ear, nose, and throat:

Gastrointestinal:

Muscular:


Neurological:

Respiratory:

Skin:

Miscellaneous:

[edit] External links

v • d • e
Antimigraine preparations (N02C)
Analgesic/abortive
Serotonin modulators
Ergot alkaloids
Other
Other
Prevention of migraines
Ungrouped
v • d • e
Tryptamines

2-Methyl-5-HT • 4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-HO-aMT • 4-HO-DIPT • 4-HO-MET • 4-MeO-DMT • 4-Methyl-aET • 4-Methyl-aMT • 5-Benzyloxytryptamine • 5-Bromo-DMT • 5-Carboxamidotryptamine • 5-Fluoro-aMT • 5-HO-aMT • 5-HTP • 5-Fluoro-DMT • 5-Methyl-DMT • 5-Methoxytryptamine • 5-MeO-7,N,N-TMT • 5-MeO-aET  • 5-MeO-aMT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MIPT • 5,7-Dihydroxytryptamine • aET • aMT • Aeruginascin • AL-37350A • BW-723C86 • Baeocystin • Bufotenidine • Bufotenin • DALT • Desformylflustrabromine • DET • DiPT • DMT • DPT • Ethocybin • EiPT • EMDT • Ethocin • FGIN-127 • FGIN-143 • Ibogaine • Iprocin • MET • MiPT • Miprocin • Melatonin • MS-245 • NAS • NMT • Norbaeocystin • Normelatonin • Oxypertine • PiPT • Psilocin • Psilocybin • Rizatriptan • Serotonin • Sumatriptan • Tryptamine • Tryptophan • Yohimbine • Yuremamine • Zolmitriptan
v • d • e
Merck & Co., Inc.
Corporate directors:
Products:
Publications:
Annual Revenue: $22.9 billion USD (?2% FY 2004) · Employees: 63,000 · Stock Symbol: NYSE: MRK · Website: www.merck.com
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Retrieved from "http://en.wikipedia.org/wiki/Rizatriptan"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rizatriptan".

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